For an oocyte to get Prepared for fertilization and progress into an embryo, the correct set of genes really should be turned on. Namekawa suspected this pre-programming from the oocyte genome happens in several phases — the initial just one starting off around the time a woman is born. He believed that chromatin remodeling proteins did A lot of this work, by shifting spools around.
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Each consists of a mass of thread-like DNA — akin to four hundred miles of yarn. To help keep it from devolving into a tangle, the DNA is wrapped all over a series of protein spools, identified as nucleosomes.
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In 2022, they discovered that a set of proteins identified as Polycomb repressive complicated one (PRC1) allows silence numerous genes across the time of start by modifying the composition of spools.
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